Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort

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TitreRelationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort
Type de publicationJournal Article
Year of Publication2021
AuteursNseir S, Martin-Loeches I, Povoa P, Metzelard M, Cheyron Ddu, Lambiotte F, Tamion F, Labruyere M, Makris D, Geronimi CBoulle, Chambrun MPinetonde, Nyunga M, Pouly O, Megarbane B, Saade A, Goma G, Magira E, Llitjos J-F, Torres A, Ioannidou I, Pierre A, Coelho L, Reignier J, Garot D, Kreitmann L, Baudel J-L, Voiriot G, Contou D, Beurton A, Asfar P, Boyer A, Thille AW, Mekontso-Dessap A, Tsolaki V, Vinsonneau C, Floch P-E, Le Guennec L, Ceccato A, Artigas A, Bouchereau M, Labreuche J, Duhamel A, Rouze A, Grp CVAPStudy
JournalCRITICAL CARE
Volume25
Pagination177
Date PublishedMAY 25
Type of ArticleArticle
ISSN1364-8535
Mots-clésCOVID-19, Mortality, Ventilator-associated pneumonia
Résumé

{Background Patients with SARS-CoV-2 infection are at higher risk for ventilator-associated pneumonia (VAP). No study has evaluated the relationship between VAP and mortality in this population, or compared this relationship between SARS-CoV-2 patients and other populations. The main objective of our study was to determine the relationship between VAP and mortality in SARS-CoV-2 patients. Methods Planned ancillary analysis of a multicenter retrospective European cohort. VAP was diagnosed using clinical, radiological and quantitative microbiological criteria. Univariable and multivariable marginal Cox's regression models, with cause-specific hazard for duration of mechanical ventilation and ICU stay, were used to compare outcomes between study groups. Extubation, and ICU discharge alive were considered as events of interest, and mortality as competing event. Findings Of 1576 included patients, 568 were SARS-CoV-2 pneumonia, 482 influenza pneumonia, and 526 no evidence of viral infection at ICU admission. VAP was associated with significantly higher risk for 28-day mortality in SARS-CoV-2 (adjusted HR 1.70 (95% CI 1.16-2.47)

DOI10.1186/s13054-021-03588-4