Total body irradiation plus fludarabine compared to busulfan plus fludarabine as ``reduced-toxicity conditioning'' for patients with acute myeloid leukemia treated with allogeneic hematopoietic cell transplantation in first complete remission: a study by
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Total body irradiation plus fludarabine compared to busulfan plus fludarabine as ``reduced-toxicity conditioning'' for patients with acute myeloid leukemia treated with allogeneic hematopoietic cell transplantation in first complete remission: a study by |
| Type de publication | Journal Article |
| Year of Publication | 2021 |
| Auteurs | Giebel S, Labopin M, Sobczyk-Kruszelnicka M, Stelljes M, Byrne JL, Fegueux N, Beelen DW, Rovira M, Spyridonidis A, Blaise D et al. |
| Journal | BONE MARROW TRANSPLANTATION |
| Volume | 56 |
| Pagination | 481-491 |
| Date Published | FEB |
| Type of Article | Article |
| ISSN | 0268-3369 |
| Résumé | {The optimal conditioning for patients with acute myeloid leukemia in first complete remission treated with allogeneic hematopoietic cell transplantation (allo-HCT) has not been defined so far. In this retrospective study, we compared two ``reduced-toxicity'' regimens: intravenous busulfan at a total dose of 9.6 mg/kg (3 days) + fludarabine (Bu3/Flu) and total body irradiation at a dose of 8 Gy + fludarabine (TBI8Gy/Flu). In the entire study cohort (n = 518), the probabilities of overall survival (OS), leukemia-free survival (LFS), relapse and non-relapse mortality (NRM) at 2 years for Bu3/Flu and TBI8Gy/Flu were 62% vs. 72.5% (p = 0.051), 59.5% vs. 65% (p = 0.15), 30% vs. 20% (p = 0.01), and 10% vs. 14% (p = 0.18), respectively. In multivariate model for patients <50 years old, TBI8Gy/Flu was associated with improved LFS (hazard ratio (HR) = 0.5 |
| DOI | 10.1038/s41409-020-01050-7 |