Continuous Sorting of Submicron Particles in a Pre-analytical Device Based on Acousto-fluidic Microsystem
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| Titre | Continuous Sorting of Submicron Particles in a Pre-analytical Device Based on Acousto-fluidic Microsystem |
| Type de publication | Conference Paper |
| Year of Publication | 2019 |
| Auteurs | Chaalane A., Guneysu D., Addouche M., Zeggari R., Lardet-Vieudrin F., Elie-Caille C., Boireau W., Khelif A. |
| Editor | Yurish SY |
| Conference Name | SENSORS AND ELECTRONIC INSTRUMENTATION ADVANCES (SEIA' 19) |
| Publisher | MDPI, Sensors Journal; MDPI, Biosensors Journal; IETI; Assun Motor; Soft Measurements & Comp; Int Frequency Sensor Assoc Publishing S L; F2D Ltd |
| Conference Location | C/ESTEVE TERRADAS, PARC UPC-PMT, EDIFICI RDIT-KAM, 1, BARCELONA, CASTELLDEFELS 08860, SPAIN |
| ISBN Number | 978-84-09-14413-6 |
| Mots-clés | Acoustic particle manipulation, Acoustic radiation force, Continuous sorting system, extracellular vesicles, Microfluidic MEMS, Standing surface acoustic wave |
| Résumé | In this work, we present a pre-analytical module based on the combination of microfluidic and electroacoustic technologies to intercept and sort submicron biological particles. It is composed by assembling a lithium niobate (LN) substrate for acoustic function and a micromachined glass substrate for microfluidic channel. The interference between the two surface acoustic waves (SAWs) generated by inter digital transducers (IDTs) create a distribution of an acoustic radiation force (ARF). This force affects differently particles depending on their physical proprieties. The device is powered by an electronic circuit with a phase shifter to move the node of the standing surface acoustic wave (SSAW) along the channel width. When the device is powered at resonance frequency, experience has shown a submicron particles alignement at a fixed position along the channel. By shifting the SSAW phase, the particles are driven to one of the three channel outlets. |