Inter/intramolecular Cherenkov radiation energy transfer (CRET) from a fluorophore with a built-in radionuclide

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TitreInter/intramolecular Cherenkov radiation energy transfer (CRET) from a fluorophore with a built-in radionuclide
Type de publicationJournal Article
Year of Publication2014
AuteursBernhard Y, Collin B, Decreau RA
JournalCHEMICAL COMMUNICATIONS
Volume50
Pagination6711-6713
Type of ArticleArticle
ISSN1359-7345
Résumé

The Cherenkov radiation (CR) from [F-18]-FDG, [Lu-177]-LuCl3 and [Y-90]-YCl3 was detected and CR energy transfer (CRET) to several fluorophores was examined. Subsequent fluorescence emission was found to be a function of the position of absorption bands with respect to the CR peak, energy of emitted particles, radionuclide/ fluorophore loading, and fluorophore brightness. A variant of the best fluorophore with a built-in radionuclide was synthesized to achieve inter-and intra-molecular CRET.

DOI10.1039/c4cc01690d