Harnessing medically relevant metals onto water-soluble subphthalocyanines: towards bimodal imaging and theranostics
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Harnessing medically relevant metals onto water-soluble subphthalocyanines: towards bimodal imaging and theranostics |
| Type de publication | Journal Article |
| Year of Publication | 2015 |
| Auteurs | Bernhard Y, Winckler P, Perrier-Cornet J-M, Decreau RA |
| Journal | DALTON TRANSACTIONS |
| Volume | 44 |
| Pagination | 3200-3208 |
| Type of Article | Article |
| ISSN | 1477-9226 |
| Résumé | Subphthalocyanine (SubPc), a putative fluorophore for optical imaging (OI), was conjugated to chelating ligands (DOTA, DTPA) affording water-soluble conjugates complexed with (non-radioactive) metals relevant to the following medical imaging techniques/therapies: MRI (Gd), PET (Cu, Ga), SPECT (In, Ga, Lu), RIT (Cu, Lu, Y), and NCT (Gd). Magneto-optical properties of ditopic gadolinium species (and optical properties of other metal containing species) were examined (brightness (epsilon x Phi(F)) and relaxivity R-1) and fluorescence confocal/biphoton microscopy studies were conducted. |
| DOI | 10.1039/c4dt03536d |