Towards the elaboration of new gold-based optical theranostics

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TitreTowards the elaboration of new gold-based optical theranostics
Type de publicationJournal Article
Year of Publication2015
AuteursDoulain P-E, Decreau R, Racoeur C, Goncalves V, Dubrez L, Bettaieb A, Le Gendre P, Denat F, Paul C, Goze C, Bodio E
JournalDALTON TRANSACTIONS
Volume44
Pagination4874-4883
Type of ArticleArticle
ISSN1477-9226
Résumé

Four new red BODIPY-gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical properties were studied. Additionally, their cytotoxicity was examined on different cancer cell lines and on a normal cell line, they were tracked in vitro by fluorescence detection, and their uptake was evaluated by ICP-MS measurements.

DOI10.1039/c4dt02977a