A genome-wide association study of marginal zone lymphoma shows association to the HLA region

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TitreA genome-wide association study of marginal zone lymphoma shows association to the HLA region
Type de publicationJournal Article
Year of Publication2015
AuteursVijai J, Wang Z, Berndt SI, Skibola CF, Slager SL, de Sanjose S, Melbye M, Glimelius B, Bracci PM, Conde L et al.
JournalNATURE COMMUNICATIONS
Volume6
Pagination5751
Date PublishedJAN
Type of ArticleArticle
ISSN2041-1723
Résumé

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
DOI10.1038/ncomms6751