Circulating Apelin is increased in patients with type 1 or type 2 diabetes and is associated with better glycaemic control
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Circulating Apelin is increased in patients with type 1 or type 2 diabetes and is associated with better glycaemic control |
| Type de publication | Journal Article |
| Year of Publication | 2014 |
| Auteurs | Habchi M, Duvillard L, Cottet V, Brindisi M-C, Bouillet B, Beacco M, Crevisy E, Buffier P, Baillot-Rudoni S, Verges B, Petit J-M |
| Journal | CLINICAL ENDOCRINOLOGY |
| Volume | 81 |
| Pagination | 696-701 |
| Date Published | NOV |
| Type of Article | Article |
| ISSN | 0300-0664 |
| Résumé | {ContextApelin is an adipokine expressed in several tissues and it appears to be involved in energy metabolism. ObjectiveThe aim of this study was to determine serum apelin levels in a large cohort of patients with type 1 and type 2 diabetes and control subjects and to correlate the results with glycaemic control. Design and ParticipantsOne hundred and thirty patients with type 1 diabetes, 98 patients with type 2 diabetes and 162 controls were enrolled in the study. Apelin levels were measured by enzyme-linked immunosorbent assay. ResultsSerum apelin levels were significantly higher in type 1 and type 2 diabetic patients than in controls (P<00001). Serum apelin levels were higher in type 1 than in type 2 diabetic patients (P=002). In multivariate analysis, serum apelin levels were higher in patients with type 1 diabetes and in patients with type 2 diabetes versus controls. We found a negative correlation between glycosylated haemoglobin and serum apelin levels in all diabetic patients (r=-017 |
| DOI | 10.1111/cen.12404 |