Gold(I) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Gold(I) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro |
| Type de publication | Journal Article |
| Year of Publication | 2014 |
| Auteurs | Serratice M., Bertrand B., Janssen E.FJ, Hemelt E., Zucca A., Cocco F., Cinellu M.A, Casini A. |
| Journal | MEDCHEMCOMM |
| Volume | 5 |
| Pagination | 1418-1422 |
| Date Published | SEP |
| Type of Article | Article |
| ISSN | 2040-2503 |
| Résumé | A number of gold(I) complexes containing the proton pump inhibitor (PPI) lansoprazole and its reduced precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methylthio)-1H-benzo [d]imidazole have been synthesized and their biological effects have been evaluated in human cancer and nontumorigenic cells in vitro. The lansoprazole-based compounds appear to act through a V-H+-ATPase-mediated mechanism. |
| DOI | 10.1039/c4md00241e |