Risk of new or recurrent cancer under immunosuppressive therapy in patients with IBD and previous cancer
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Risk of new or recurrent cancer under immunosuppressive therapy in patients with IBD and previous cancer |
| Type de publication | Journal Article |
| Year of Publication | 2014 |
| Auteurs | Beaugerie L, Carrat F, Colombel J-F, Bouvier A-M, Sokol H, Babouri A, Carbonnel F, Laharie D, Faucheron J-L, Simon T, de Gramont A, Peyrin-Biroulet L, Group CESAMEStudy |
| Journal | GUT |
| Volume | 63 |
| Pagination | 1416-1423 |
| Date Published | SEP |
| Type of Article | Article |
| ISSN | 0017-5749 |
| Résumé | {Objective To explore the risk of new or recurrent cancer among patients with IBD and previous cancer, exposed or not to immunosuppressants. Design Among the 17 047 patients of the CESAME prospective observational cohort who were enrolled from May 2004 to June 2005, and followed-up until December 2007, we identified 405 patients with cancer diagnosed previous to study entry. We calculated the rates of incident cancer in patients with or without previous cancer, and we assessed by survival analysis and nested case-control study the impact of immunosuppressants on the risk of incident new or recurrent cancer in patients with previous cancer. Results The rate of incident cancer was 21.1/1000 patient-years (PY) and 6.1/1000 PY in patients with and without previous cancer, respectively. The multivariate-adjusted HR of incident cancer between patients with and without previous cancer was 1.9 (95% CI 1.2 to 3.0 |
| DOI | 10.1136/gutjnl-2013-305763 |