A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells

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TitreA novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells
Type de publicationJournal Article
Year of Publication2020
AuteursGorbatov SA, Uvarov DYu., Scherbakov AM, Zavarzin IV, Volkova YA, Romieu A
JournalMENDELEEV COMMUNICATIONS
Volume30
Pagination750-752
Date PublishedNOV-DEC
Type of ArticleArticle
ISSN0959-9436
Mots-clésBODIPY, Fluorescent probe, hypoxia, Lung cancer, nitroreductase
Résumé

The development of effective methods for real-time monitoring of nitroreductase (NTR) activity is of great significance for medical diagnosis and cancer research. Here, we present a novel water-soluble BODIPY-based chemodosimeter (NBB) for imaging the hypoxic status of human non-small-cell lung cancer A549 cells. We assume that `on-off' response of NBB is activated by the NTRmediated reductive release of meso-phenol BODIPY dye resulting in unusual fluorescence.
DOI10.1016/j.mencom.2020.11.020