Synthesis and Antiviral Activity Evaluation of Nitroporphyrins and Nitrocorroles as Potential Agents against Human Cytomegalovirus Infection
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Synthesis and Antiviral Activity Evaluation of Nitroporphyrins and Nitrocorroles as Potential Agents against Human Cytomegalovirus Infection |
| Type de publication | Journal Article |
| Year of Publication | 2015 |
| Auteurs | Gros CP, Desbois N, Michelin C, Demilly E, Tilkin-Mariame A-F, Mariame B, Gallardo F |
| Journal | ACS INFECTIOUS DISEASES |
| Volume | 1 |
| Pagination | 350-356 |
| Date Published | AUG |
| Type of Article | Article |
| ISSN | 2373-8227 |
| Mots-clés | antiproliferative activities, human Cytomegalovirus, in vivo toxicity, nitrocorroles, nitroporphyrins |
| Résumé | Different nitroporphyrinoid derivatives were synthesized and studied as potential agents against human Cytomegalovirus. Interestingly, two nitrocorroles display strong activity against human Cytomegalovirus with IC50 < 0.5 mu M. These compounds also possess antiproliferative activities without detected in vivo toxicity. Therefore, nitrocorroles appear for the first time as potential active compounds that can be applied in human health. |
| DOI | 10.1021/acsinfecdis.5b00020 |