Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma |
| Type de publication | Journal Article |
| Year of Publication | 2017 |
| Auteurs | Bernatsky S, Garcia HAVelasqu, Spinelli JJ, Gaffney P, Smedby KE, Ramsey-Goldman R, Wang SS, Adami H-O, Albanes D, Angelucci E et al. |
| Journal | LUPUS SCIENCE & MEDICINE |
| Volume | 4 |
| Pagination | UNSP e000187 |
| Date Published | JAN |
| Type of Article | Article |
| ISSN | 2053-8790 |
| Résumé | {Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16 |
| DOI | 10.1136/lupus-2016-000187 |