Circulating NKp46(+) Natural Killer cells have a potential regulatory property and predict distinct survival in Non-Small Cell Lung Cancer

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TitreCirculating NKp46(+) Natural Killer cells have a potential regulatory property and predict distinct survival in Non-Small Cell Lung Cancer
Type de publicationJournal Article
Year of Publication2019
AuteursPicard E, Godet Y, Laheurte C, Dosset M, Galaine J, Beziaud L, Loyon R, Boullerot L, Joseph ELauret Mar, Spehner L, Jacquin M, Eberst G, Gaugler B, Le Pimpec-Barthes F, Fabre E, Westeel V, Caignard A, Borg C, Adotevi O
JournalONCOIMMUNOLOGY
Volume8
Paginatione1527498
Type of ArticleArticle
ISSN2162-402X
Mots-clésCD16, NK cells, NKp46, NSCLC, prognosis
Résumé

{Natural killer (NK) cells are innate effector lymphocytes widely involved in cancer immunosurveillance. In this study, we described three circulating NK cell subsets in patients with non-small cell lung cancer (NSCLC). Compared to healthy donors (HD), lower rate of the cytotoxic CD56(dim) CD16(+) NK cells was found in NSCLC patients (76.1% vs 82.4%

DOI10.1080/2162402X.2018.1527498