Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study
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| Titre | Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study |
| Type de publication | Journal Article |
| Year of Publication | 2019 |
| Auteurs | Busch C, Iglicki M, Okada M, Gabrielle P-H, Cohen S, Mariussi M, Amphornphruet A, Cebeci Z, Chaikitmongkol V, Couturier A, Fraser-Bell S, Fung AT, Iannetta D, Radecka L, Lains I, Rodrigues TM, Lupidi M, Ozimek M, Sala-Puigdollers A, Rehak M, Loewenstein A, Zur D, IRG |
| Journal | OPHTHALMOLOGICA |
| Volume | 241 |
| Pagination | 211-219 |
| Type of Article | Article |
| ISSN | 0030-3755 |
| Mots-clés | Endophthalmitis, Intravitreal injection, vascular endothelial growth factor |
| Résumé | Purpose: The main objective of this study was to investigate the microbiological spectrum of endophthalmitis after anti-VEGF injections and to compare streptococcal with non-streptococcus-associated cases with regard to baseline characteristics and injection procedure. Methods: Retrospective, international multicenter study of patients with culture-positive endophthalmitis after intravitreal anti-VEGF injection at 17 different retina referral centers. Results: Eighty-three cases with 87 identified pathogens were included. Coagulase-negative staphylococci (59%) and viridans streptococci (15%) were the most frequent pathogens found. The use of postoperative antibiotics and performance of injections in an operating room setting significantly reduced the rate of streptococcus-induced endophthalmitis cases (p = 0.01 for both). Conclusion: We found a statistically significant lower rate of postinjectional local antibiotic therapy and operating room-based procedures among the streptococcus-induced cases compared to cases caused by other organisms. (C) 2019 S. Karger AG, Basel |
| DOI | 10.1159/000496942 |