Circulating levels of 3-hydroxymyristate, a direct quantification of endotoxaemia in noninfected cirrhotic patients

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TitreCirculating levels of 3-hydroxymyristate, a direct quantification of endotoxaemia in noninfected cirrhotic patients
Type de publicationJournal Article
Year of Publication2019
AuteursWeil D, de Barros J-PPais, Mourey G, Laheurte C, Cypriani B, Badet N, Delabrousse E, Grandclement E, Di Martino V, Saas P, Lagrost L, Thevenot T
JournalLIVER INTERNATIONAL
Volume39
Pagination106-114
Date PublishedJAN
Type of ArticleArticle
ISSN1478-3223
Mots-clés3-hydroxymyristate, bacterial translocation, cirrhosis, endotoxaemia, lipopolysaccharide, portal hypertension
Résumé

{Background & Aims The quantification of lipopolysaccharide (LPS) in biological fluids is challenging. We aimed to measure plasma LPS concentration using a new method of direct quantification of 3-hydroxymyristate (3-HM), a lipid component of LPS, and to evaluate correlations between 3-HM and markers of liver function, endothelial activation, portal hypertension and enterocyte damage. Methods Plasma from 90 noninfected cirrhotic patients (30 Child-Pugh [CP]-A, 30 CP-B, 30 CP-C) was prospectively collected. The concentration of 3-HM was determined by high-performance liquid chromatography coupled with mass spectrometry. Results 3-HM levels were higher in CP-C patients (CP-A/CP-B/CP-C: 68/70/103 ng/mL
DOI10.1111/liv.13916