Gold(I)-BODIPY-imidazole bimetallic complexes as new potential anti-inflammatory and anticancer trackable agents

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TitreGold(I)-BODIPY-imidazole bimetallic complexes as new potential anti-inflammatory and anticancer trackable agents
Type de publicationJournal Article
Year of Publication2017
AuteursTrommenschlager A, Chotard F, Bertrand B, Amor S, Dondaine L, Picquet M, Richard P, Bettaieb A, Le Gendre P, Paul C, Goze C, Bodio E
JournalDALTON TRANSACTIONS
Volume46
Pagination8051-8056
Date PublishedJUL 7
Type of ArticleArticle
ISSN1477-9226
Résumé

Two new gold(I)-BODIPY-imidazole based trackable therapeutic bimetallic complexes have been synthesized and fully characterized. They display strong antiproliferative properties on several types of cancers including colon, breast, and prostate and one of them presents a significant anti-inflammatory effect. Additionally, the two compounds could be visualised in vitro by confocal microscopy in the submicromolar range.

DOI10.1039/c7dt01377a