Design of new sensitive alpha,beta-unsaturated carbonyl 1,8-naphtalimide fluorescent probes for thiol bioimaging
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Design of new sensitive alpha,beta-unsaturated carbonyl 1,8-naphtalimide fluorescent probes for thiol bioimaging |
| Type de publication | Journal Article |
| Year of Publication | 2017 |
| Auteurs | Sok N, Nikolantonaki M, Guyot S, Nguyen TDat, Viaux A-S, Bagala F, Rousselin Y, Husson F, Gougeon R, Saurel R |
| Journal | SENSORS AND ACTUATORS B-CHEMICAL |
| Volume | 242 |
| Pagination | 865-871 |
| Date Published | APR |
| Type of Article | Article |
| ISSN | 0925-4005 |
| Mots-clés | Bioimaging, Biological thiols, Michael's addition, Thiol probes, Turn-ON fluorescence |
| Résumé | We report herein an efficient synthesis of news naphtalimide-based fluorescent derivatives functionalized with an a,(3-unsaturated carbonyl group. Probes were synthesized from reaction of an amino-naphtalimide precursor with maleic anhydride. Photophysical study of fluorescent probes and cells labelling were performed, and showed that the reactive derivatives exhibit rich turn on fluorescence properties in presence of different biological thiol (Glutathione and Cysteine) making these systems a very promising way for thiol bioimaging. (C) 2016 Elsevier B.V. All rights reserved. |
| DOI | 10.1016/j.snb.2016.09.171 |