5-Amino-6,7,8,9-Tetrahydrobenzo[b][1,8]Naphthyridin-2(1H)-One: The first Example of a new Family of HuperTacrines for Alzheimer's Disease Therapy
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | 5-Amino-6,7,8,9-Tetrahydrobenzo[b][1,8]Naphthyridin-2(1H)-One: The first Example of a new Family of HuperTacrines for Alzheimer's Disease Therapy |
| Type de publication | Journal Article |
| Year of Publication | 2017 |
| Auteurs | Balmori A, Chioua M, de la Bellacasa RPuig, Estrada-Tejedor R, Ismaili L, Marco-Contelles J, Borrell JI |
| Journal | CHEMISTRYSELECT |
| Volume | 2 |
| Pagination | 2605-2610 |
| Date Published | MAR 13 |
| Type of Article | Article |
| ISSN | 2365-6549 |
| Mots-clés | Alzheimer's disease, HuperTacrines, Huperzin, synthesis, tacrine |
| Résumé | In this communication we have described the synthesis of 2-amino-6-oxo-1,6-dihydropyridine-3-carbonitrile (4), and the preparation of 5-amino-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridin-2(1H)-one (3a), a non-hepatotoxic, antioxidant agent, showing moderate, but selective human acetylcholinesterase inhibition. |
| DOI | 10.1002/slct.201700289 |