Inflammasomes and Natural Ingredients towards New Anti-Inflammatory Agents

Affiliation auteursAffiliation ok
TitreInflammasomes and Natural Ingredients towards New Anti-Inflammatory Agents
Type de publicationJournal Article
Year of Publication2016
AuteursDutartre P
JournalMOLECULES
Volume21
Pagination1492
Date PublishedNOV
Type of ArticleReview
Mots-clésinflammasomes, inflammation, Natural antioxidants
Résumé

Inflammasomes are a family of proteins in charge of the initiation of inflammatory process during innate immune response. They are now considered major actors in many chronic inflammatory diseases. However, no major drug focusing on this target is currently on the market. Among the various approaches aiming to control this major metabolic pathway, compounds aiming to modify the intracellular antioxidant profile appear to be promising. This can be obtained by ``light'' antioxidants able to induce natural antioxidant response of the cell itself. This review will give an overview of the current available information on this promising pharmacology approach.

DOI10.3390/molecules21111492