Divergent Synthesis of Dihydroxanthene-Hemicyanine Fused Near-Infrared Fluorophores through the Late-Stage Amination of a Bifunctional Precursor

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TitreDivergent Synthesis of Dihydroxanthene-Hemicyanine Fused Near-Infrared Fluorophores through the Late-Stage Amination of a Bifunctional Precursor
Type de publicationJournal Article
Year of Publication2016
AuteursOng MJui Hsien, Srinivasan R, Romieu A, Richard J-A
JournalORGANIC LETTERS
Volume18
Pagination5122-5125
Date PublishedOCT 7
Type of ArticleArticle
ISSN1523-7060
Résumé

A late-stage amination of a bifunctional dihydroxanthene (DHX) scaffold is reported to access a wide variety of new near-infrared (NIR) chromophores/fluorophores. The divergent approach allows the coupling of aliphatic and aromatic amines and readily provides molecular diversity shedding light on the structure fluorescence relationship of this emerging class of NIR fluorophores.

DOI10.1021/acs.orglett.6b02564