HPV DNA genotyping: A study of anogenital, head and neck and skin cancers in a population from west Algerian. HPV detection in different cancers from an Algerian population

Objectives > To investigate the prevalence of human papillomaviruses (HPV) in cancers located at different sites in patients from west Algerian and collected between 2010 and 2014. Material and methods > Extracted DNA from archival formaldehyde-fixed and paraffin-embedded tissues was provided from 39 anogenital cancers, 10 head and neck cancers and 36 skin cancers. The viral DNA was detected using the INNO-LiPA HPV Genotyping Extra (R) kit. Results > The prevalence of HPV was 100 % in cervical cancers, 40 % in vaginal cancers, 17 % in vulvar cancers, 33 % in anal cancers, 0 % in tonsil and larynx cancers and 6.4 % in skin squamous cell carcinoma. In cervical cancers, the most prevalent genotypes were HPV16 (52 %) and HPV18 (12 %) as single infection. Conclusion > The overall results agree partially with literature. Extensive research is necessary to promote HPV vaccine to reduce in particular the burden of cervical cancer in Algeria.